The Abstracts of the paper carried by the Journal of JACA
There is a growing need to reduce energy consumption as well as the running costs of production plants. However, achieving energy savings within large space cleanrooms presents a significant challenge, because it is difficult to achieve solely by tuning the conventional air-conditioning systems used in cleanrooms, i.e., fan filter units.
In this study, we have applied a swirling-induction-type HVAC system (SWIT) to a cleanroom. This system is able to efficiently cool and filter the air in large spaces. This report provides a basic technical explanation of the use of the Takasago clean room swirling-induction-type HVAC system (TCR-SWIT) in cleanrooms and discusses the case study conducted to verify the effectiveness of the system.
The energy-saving potential of the SWIT is widely recognized, and they are currently used by many customers. In addition, the “SWIT Energy Efficiency Renewal Project” won the 2012 Energy Efficiency Grand Prize (Product and Business Model Category).
TCR-SWIT have achieved sales records since 2006 and have demonstrated an extremely high energy-saving potential at a low cost. Therefore, the system is expected to achieve significant results in the field of cleanroom air conditioning and become the standard in the next generation cleanroom air conditioning systems.
We have developed biosafety cabinet (BSC) which has been improved by the Air Isolation System (AIS) with double air flow barriers. The main operation area in the AIS is Grade A cleanliness, and of course the work area of BSC is Grade A too. The Airflow from AIS does not leak out to work area of BSC. The AIS has very narrow space to decontaminate, because AIS does not have work table and interior work surface.
We have evaluated that containment airflow of the AIS and BSC by personnel, product, and cross-contamination protection test, according to standard of class II biosafety cabinets (JIS K3800:2009).
The concentration of formaldehyde in the work environment has been regulated to less than 0.1ppm in Japan in 2008. In pathology labs of hospitals, measures to prevent workers from being exposed to formaldehyde must be taken. To resolve this problem, we have developed the local exhaust device using the U-shaped airflow. We have installed this technology for a hospital in Niigata Prefecture in 2015, and confirmed its performance. As a result, the concentration of formaldehyde in pathology labs has achieved less than 0.1ppm.
Chemical substances having many useful properties are used for many purposes such as the raw materials of the products, manufacturing process and medical care site. It is estimated that about 65,000 chemical substances have been used already and approximately 1,000 are newly introduced in every year. In these chemical substances, some have a hazardous property of explosion, fire or abnormal reaction, as well as acute and chronic poisoning to human. However, many of those chemical substances have not been cleared their hazardous properties, and those cleared are only several thousands hitherto.
The objective of this paper is to implement the risk reduction measures of many harmful chemical substance emitted in a work place. In recent years, push-pull type ventilation systems have been used to implement the risk reduction measures in many work places. Therefore, this paper describes an overview and a design of push-pull type ventilation systems for working environment improvement.
An example of designing a containment facility for a synthetic drug substance plant with Highly Potent Active Pharmaceutical Ingredients
The anticancer drug is a representative of highly potent active pharmaceuticals, but is effective in treating the patient, it is also a substance that is likely to cause health problems for operators in the pharmaceutical manufacturing plant.
Therefore, in the plant that handles Highly Potent Active Pharmaceutical Ingredients, they are produced by carying out the containment handling so that they do not scatter.
This paper shows an example of a pharmaceutical manufacturing plant, especially a synthetic drug plant, and explain how to select containment facilities from the containment conditions presented by customers and design them as a system.